Aminoglycoside Dosing in HD-beginning or end of treatment

We reviewed the evidence regarding AMG dosing in HD patients. A few recent articles suggest administration of the AMG (e.g. tobramycin 1.5 mg/kg) at beginning rather than the end of HD to optimize Peak/MIC and AUC/MIC ratios.

Does anyone have experience with method? How do you currently dose AMG?

Piera Calissi
Saskatoon Health Region